Featured Publications
An intranasal ASO therapeutic targeting SARS-CoV-2
Zhu C, Lee JY, Woo JZ, Xu L, Nguyenla X, Yamashiro LH, Ji F, Biering SB, Van Dis E, Gonzalez F, Fox D, Wehri E, Rustagi A, Pinsky BA, Schaletzky J, Blish CA, Chiu C, Harris E, Sadreyev RI, Stanley S, Kauppinen, S, Rouskin S, Näär AM.
Nature Communications 2022. 13:4503. https://doi.org/10.1038/s41467-022-32216-0
A microRNA linking human positive selection and metabolic disorders
Wang L, Sinnott-Armstrong N, Wagschal A, Wark A, Camporez JP, Perry RJ, Ji F, Sohn Y, Oh J,
Wu S, Chery J, Moud BN, Saadat A, Dankel SN, Mellgren G, Tallapragada DSP, Strobel SM, Lee MJ, Tewhey R, Sabeti PC, Schaefer A, Petri A, Kauppinen S, Chung RT, Soukas A, Avruch J, Fried S, Hauner H, Sadreyev RI, Shulman GI, Claussnitzer M, and Näär AM.
Cell 2020. 183: 684-701. PMID: 33058756
Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis
Wagschal A, Najafi-Shoushtari SH, Wang L, Goedeke L, Sinha S, Delemos AS, Black JC, Ramirez CM, Li X, Tewhey R, Hatoum I, Shah N, Lu Y, Kristo F, Psychogios N, Vrbanac V, Lu Y-C, Hla T, de Cabo R, Tsang JS, Schadt E, Sabeti PC, Kathiresan S, Cohen DE, Whetstine J, Chung RT, Fernández-Hernando C, Kaplan LM, Bernards A, Gerszten RE, and Näär AM.
Nature Medicine 2015. 21:1290-1297. PMCID: PMC4993048.
Selected Publications
Regulatory networks in mediating selective transcriptional output
Kato, Y, Habas, R, Katsuyama, Y, Näär, AM, and He, X. A component of the ARC/Mediator complex required for TGF-ß/Nodal signaling. Nature 2002. 418:641-646.
Thakur, JK, Arthanari, H, Yang, F, Pan, S-J, Fang, X, Breger, J, Frueh, DP, Gulshan, K, Li, DK, Mylonakis, E, Struhl, K, Moye-Rowley, WS, Cormack, B, Wagner, G, and Näär, AM. A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature [Article] 2008. 452:604-609.
Morris, EJ, Ji, J-Y, Yang, F, Di Stefano, L, Herr, A, Moon, N-S, Kwon, EJ, Haigis, KM, Näär, AM, and Dyson, NJ. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature 2008. 455:552-556. PMCID: PMC3148807.
Nishikawa, JL, Boeszoermenyi, A, Vale-Silva, LA, Torelli, R, Posteraro, B, Sohn, YJ, Ji, F, Gelev, V, Sanglard, D, Sanguinetti, M, Sadreyev, RI, Mukherjee, G, Bhyravabhotla, J, Buhrlage, SJ, Gray, NS, Wagner, G*, Näär, AM*, and Arthanari, H*. Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. Nature 2016. 25;530(7591):485-489. PMCID: PMC4860947. *Co- corresponding authors.
Selected Publications
SREBP mechanistic principles and insulin regulation
Yang, F, Vought, BW, Satterlee, JS, Walker, AK, Sun, Z-YJ, Watts, JL, DeBeaumont, R, Saito, RM, Hyberts, SG, Yang, S, Macol, C, Iyer, L, Tjian, R, van den Heuvel, S, Hart, AC, Wagner, G, and Näär, AM. An ARC/Mediator subunit required for SREBP regulation of cholesterol and fatty acid homeostasis. Nature 2006. 442:700-704.
Walker, AK, Yang, F, Jiang, K, Ji, J-Y, Watts, JL, Purushotham, A, Boss, O, Hirsch, M, Ribich, S, Smith, JJ, Israelian, K, Westphal, CH, Rodgers, JT, Shioda, T, Elson, S, Mulligan, P, Najafi-Shoushtari, SH, Black, JC, Thakur, JT, Kadyk, LC, Whetstine, J, Mostoslavsky, R, Puigserver, P, Li, X, Dyson, NJ, Hart, AC, and Näär, AM. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes & Development 2010. 24:1403-1417. PMCID: PMC2895199.
Walker, AK, Jacobs, RL, Watts, JL, Rottiers, V, Jiang, K, Finnegan, DM, Shioda, T, Hansen, M, Yang, F, Niebergall, L, Vance, D, Tzoneva, M, Hart, AC, Näär, AM. A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell 2011. 147:840-852. PMCID: PMC3384509.
Hancock, ML, Meyer, R, Mistry, M, Wagschal, A, Khetani, RS, Shin, T, Sui, SH, Näär, AM, and Flanagan, JG. Insulin receptor associates with promoters genome-wide and regulates gene expression. Cell 2019. 177:1-15 (published online 4/4/19). PMCID: PMC6478446. Highlighted in Nature Reviews Endocrinol and Cell Res.
Hong, X, Roh, W, Sullivan, RJ, Wong, KHK, Wittner, BS, Guo, H, Dubash, TD, Sade-Feldman, M, Wesley, BK, Horwitz, E, Boland, GM, Marvin, DL, Bonesteel, T, Lu, C, Aguet, F, Burr, R, Freeman, SS, Parida, L, Calhoun, K, Jewett, MK, Nieman, LT, Hacohen, N, Näär, AM, Ting, DT, Toner, M, Stott, SL, Getz, G, Maheswaran, S, and Haber, DA. The lipogenic regulator SREBP2 induces Transferrin in circulating melanoma cells and suppresses ferroptosis. Cancer Discovery 2021 Mar;11(3):678-695. doi: 10.1158/2159-8290.CD-19-1500.Epub 2020 Nov 17. Highlighted in Front Cell Dev Biol.
Selected Publications
microRNAs (miRNAs) guiding metabolic homeostasis
Gnanaguru, G, Wagschal, A, Oh, J, Saez-Torres, KL, Li, T, Temel, R, Kleinman, ME, Näär, AM*, and D’Amore, P*. Targeting of miR-33 ameliorates phenotypes linked to age-related macular degeneration. Molecular Therapy 2021 Mar 17;S1525-0016(21)00143-X. doi: 10.1016/j.ymthe.2021.03.014. *Co-corresponding authors.
Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, Delemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM. Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR. Science Translational Medicine 2013. 5:212ra162. PMCID: PMC4033576.
Selected Publications
Antisense oligonucleotides in antiviral therapeutic targeting
Chery, J, Petri, A, Wagschal, A, Lim, SY, Cunningham, J, Vasudevan, S, Kauppinen, S, Näär, AM. Development of Locked Nucleic Acid antisense oligonucleotide therapeutics targeting Ebola proteins and host factor NPC1. Nucleic Acid Therapeutics 2018. 28:273-284.
Gorgulla C, Padmanabha Das KM, Leigh KE, Cespugli M, Fischer PD, Wang ZF, Tesseyre G, Pandita S, Shnapir A, Calderaio A, Gechev M, Rose A, Lewis N, Hutcheson C, Yaffe E, Luxenburg R, Herce HD, Durmaz V, Halazonetis TD, Fackeldey K, Patten JJ, Chuprina A, Dziuba I, Plekhova A, Moroz Y, Radchenko D, Tarkhanova O, Yavnyuk I, Gruber C, Yust R, Payne D, Näär AM, Namchuk MN, Davey RA, Wagner G, Kinney J, Arthanari H. A multi-pronged approach targeting SARS-CoV-2 proteins using ultra- large virtual screening. iScience 2021. 24:102021. doi: 10.1016/j.isci.2020.102021. Epub 2021 Jan 5.
